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Booster Shots Drastically Reduce Delta Variant Hospitalizations And Deaths In Israel
The first large-scale real-world study of the effectiveness of booster shots against COVID-19 has found them to be up to 93 percent protective, even against the Delta variant.
The study is based on the period from July 30 to September 23 this year, coinciding with most of Israel’s fourth wave, which peaked in early September with around 10,000 cases and 30 deaths a day. Almost all the infections were from the Delta variant.
The authors compared 728,321 people who received a third dose of the Pfizer vaccine with an identical number of people who had their second Pfizer injection at least five months earlier, but had yet to receive a booster. The second group were carefully chosen to match the first as closely as possible, on characteristics including age, sex, location, health status, and known risk-taking and risk-avoiding behavior.
The most dramatic finding was that more than a week after getting the booster shot a person’s risk of hospitalization for COVID-19 was 93 percent lower than someone with similar characteristics, but only two shots. The booster was almost as protective for being classified as having severe COVID at 92 percent, and for testing positive for COVID-19 (88 percent) and having any noticeable symptoms (91 percent).
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02249-2/fulltext
The results are similar to a previous study that did not control for pre-existing conditions: https://www.nejm.org/doi/10.1056/NEJMoa2114255
